Strattera side effects — what you need to know

Started Strattera (atomoxetine) or thinking about it? Good to know what can happen. Strattera is not a stimulant like some ADHD drugs, but it still affects your body and mood. Below I break down the common problems, the rare but serious ones, and simple steps you can take to stay safe.

Common and manageable side effects

Most people who take Strattera get one or more mild side effects in the first few weeks. These often lessen as your body adjusts. Expect stuff like: nausea, upset stomach, decreased appetite, dry mouth, constipation, dizziness, tiredness, and trouble sleeping. Some people notice changes in mood — more irritability or feeling down — or small rises in heart rate and blood pressure.

Simple tips that help: take your dose with food to cut nausea, drink more water for dry mouth and constipation, and try a light snack if appetite drops. If sleep is a problem, avoid late afternoon doses and use good sleep habits (dark room, no screens before bed). If weight drops suddenly or you can’t sleep for days, tell your doctor.

Serious risks and when to call your doctor

Serious problems are less common, but you should know them. Strattera can raise blood pressure and heart rate enough to matter, especially if you already have heart conditions. It can cause liver injury in a small number of people — look out for yellowing skin or eyes, dark urine, or belly pain. In children and teens, atomoxetine has been linked to increased suicidal thoughts in rare cases; watch mood closely during the first months.

Other rare but urgent issues include allergic reactions (hives, swelling, trouble breathing) and priapism — a painful erection that won’t go away. If you notice any of these, get medical help right away.

Drug interactions matter. Don’t mix Strattera with MAO inhibitors or certain blood pressure meds without checking with your doctor. Tell your prescriber about all drugs and supplements you take, including herbal products and OTC cold meds. Also mention any history of heart disease, high blood pressure, liver problems, bipolar disorder, or glaucoma.

How doctors monitor you: expect a baseline check of blood pressure and pulse, and follow-ups after starting or changing dose. If symptoms suggest liver trouble or severe mood changes, your doctor may order blood tests or change the medication.

Bottom line: many people tolerate Strattera well and get clear benefits for ADHD. Still, watch for changes in mood, blood pressure, appetite, and liver signs. If anything feels off or severe, call your healthcare provider. Quick action can prevent small side effects from becoming big problems.